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KMID : 1007520100190010219
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Food Science and Biotechnology
2010 Volume.19 No. 1 p.219 ~ p.227
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Nutrigenomic Analysis of Hypolipidemic Effects of Agastache rugosa Essential Oils in HepG2 Cells and C57BL/6 Mice
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Jun Hee-Jin
Chung Mi-Ja
Kevin Dawson
Raymond L. Rodriguez
Houng Soung-Jin
Cho Sung-Yun
Jungae Jeun
Kim Jin-Young
Kim Kyung-Heon
Park Kuen-Woo
Kim Cheong-Tae
Lee Sung-Joon
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Abstract
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Hypolipidemic effects of Agastache rugosa essential oil (AREO) were investigated. Gas chromatographymass spectrometry (GC-MS) analysis showed that the major compound in AREO is limonene (47%, w/w). AREO (1 mg/mL) markedly reduced low density lipoprotein (LDL) oxidation (?93%). After 3-week feeding of AREO, plasma cholesterol (?28%) and triglyceride levels (?26%) were significantly decreased in C57BL/6J mice. Mouse hepatic transcriptome profiling with oligonucleotide microarray revealed that AREO altered the expression of 2,524 genes. Notably, significant reductions in sterol regulatory element binding factor (SREBF)-1 and SREBF- 2 mRNA levels were detected. Protein expression of HMG-CoA reductase, a major target for SREBP-2, was reduced in HepG2 cells (?36%) and in mouse liver (?35 %). AREO also significantly increased mRNA (+40%) and protein (+83%) expression of the LDL receptor in HepG2 cells and mouse liver, respectively. Our findings suggest that AREO may prevent atherosclerosis via the inhibition of LDL oxidation, down-regulation of SREBF-2 and HMG-CoA reductase expression, and up-regulation of LDL receptor expression.
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KEYWORD
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Agastache rugosa (Korean mint), cholesterol, herbal essential oil, hypocholesterolemic effect
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